The therapeutic effect develops after 2 weeks after initiation of therapy, reaching a maximum of 4 weeks and maintained throughout the treatment period. Absorption and distribution.Absorption – high. The maximum plasma concentration after oral administration is achieved afterwomen above 20%, the area under the curve “concentration-time” lower than that of men, which oxymetholone for sale has no clinical significance. Patients with alcoholic liver cirrhosis however decrease cholesterol is similar to that in the application of atorvastatin without simultaneous food intake. after oral administration of atorvastatin in the evening in the blood plasma concentration lower and “primary pass” through the liver.
The average distribution volume – 381 liters, the connection with plasma proteins -. 98% The ratio of atorvastatin concentration in erythrocytes / plasma is about 0 25, i.e. atorvastatin poorly penetrates into erythrocytes. Metabolism and excretion. atorvastatin is metabolized primarily in the liver under the influence of isozymes to form pharmacologically active metabolites (ortho paragidroksilirovannyh and derivatives, beta-oxidation products). in vitro ortho and paragidroksilirovannye metabolites have an inhibitory effect reductase, comparable to that of atorvastatin. The inhibitory effect of the drug against reductase inhibitor of approximately 70% determined by the activity of circulating metabolites that persists for about 20 -. 30 hours, due to their presence results of the research in vitro give grounds to assume that the isoenzymeliver plays an important role in the metabolism atorvastatin. This is confirmed by an increase in plasma concentrations of atorvastatin while taking erythromycin, which is also an inhibitor of that isoenzyme. Studies in vitro have also shown that atorvastatin is a weak inhibitor of isozyme . Write mainly through the intestine after hepatic and / or extrahepatic metabolism (the drug is not exposed to pronounced enterohepatic recirculation). Less than 2% of an oral dose is determined in urine. Not output during dialysis due to intense binding to plasma proteins. C max and AUC of the drug in elderly patients (70 years and older) at 40 and 30%, respectively, higher than that of young patients, but this has no clinical significance. renal function does not affect the concentration of drug in blood plasma.
The drug oxymetholone for sale is used:
• in combination with a cholesterol-lowering diet to reduce elevated total cholesterol, cholesterol, apolipoprotein B, and triglycerides, and increase the concentration in patients with primary hypercholesterolemia, heterozygous familial and non-familial hypercholesterolaemia and combined (mixed) hyperlipidemia ( type IIa and IIb Fredrickson classification) when diet therapy and other non-pharmacological treatments are not sufficiently effective;
• to reduce the concentration of total cholesterol oxymetholone for sale cholesterol in patients with homozygous familial hypercholesterolemia, when diet therapy and other non-pharmacological treatments are not sufficiently effective;
• primary prevention of cardiovascular complications in patients without clinical evidence of coronary heart disease but with multiple risk factors for its development: age over 55 years, nicotine addiction, hypertension, diabetes mellitus, retinopathy, albuminuria, low concentrations cholesterol in the blood plasma, genetic predisposition, including against the background of dyslipidemia;
• secondary prevention of cardiovascular events in patients with coronary heart disease to reduce total mortality, myocardial infarction, stroke, rehospitalization for angina oxymetholone for sale and the need for revascularization.