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anadrol 50 dosage

Bioavailability chlorprothixene when administered orally is about 12%. Chlorprothixene rapidly absorbed from the intestine, the maximum serum concentration achieved after 2 h. The half-life time is about 16 hours. Chlorprothixenum crosses the placental barrier in small amounts excreted in breast milk. The metabolites have no antipsychotic activity, excreted in the feces and urine.

Indications
Truksal is a sedative neuroleptic with anadrol 50 dosage a wide range of indications, which include:

 

  • psychoses, including schizophrenia and manic states, occurring with psychomotor agitation, agitation and anxiety,
  • hangover withdrawal syndrome in alcoholism and drug addiction,
  • hyperactivity, irritability, agitation, confusion in elderly patients,
  • behavioral disorders in children,
  • depression, neurosis, psychosomatic disorders,
  • insomnia,
  • pain (in combination with analgesics).Contraindications
    CNS depression of any origin (including those caused by the intake of alcohol, barbiturates or opiates), coma, circulatory collapse, diseases of the blood, pheochromocytoma.
    Increased sensitivity to the drug.
    Truksal should not, if possible, be given to pregnant women and breast feeding.

    Dosing and Administration

    . Psychosis, including schizophrenia and manic states starts 50 – 100 mg / day, gradually increasing the dose until the optimum effect, typically up to 300 mg / day. In some cases the dose may be increased up to 1200 mg / day. The maintenance dose is usually 100 – 200 mg / day.
    The daily  usually divided into 2 – 3 admission, given the expressed sedative , are encouraged to nominate a smaller part of a daily dose during the day, and a large part – in the evening.

    Hangover withdrawal syndrome in alcoholism and drug addiction.
    The daily dose divided into 2 – 3 admission is 500 mg. The course of treatment usually lasts for 7 days. After the disappearance of the manifestations of abstinence dose is gradually reduced. Maintenance dose 15 – 45 mg / day to stabilize the condition, it reduces the risk of another binge.

    In elderly patients, the presence of hyperactivity, irritability, agitation, confusion appointed by 15 – 90 mg / day. The daily dose is usually divided into 3 doses.

    In children, for correction of behavior Truksal assigned rate of 0.5 – 2 mg per 1 kg of body weight.

    Depressive states, neurosis, psychosomatic disorders. Can be used for depression, especially combined with anxiety, stress, as an adjunct to antidepressant therapy or independently.  Can be administered in the neuroses and psychosomatic disorders involving anxiety and depressive disorders, and 90 mg / day. The daily dose is usually divided into 2-3 doses. Since receiving  causes of addiction or drug dependence, it can be used for a long time.

    Insomnia . On 15 – 30 mg in the evening for 1 hour before bedtime.

    Pain. The ability to potentiate the effects of analgesics Truksala can be used in the treatment of patients with pain. In these cases Truksal administered together with anadrol 50 dosage analgesics at doses ranging from 15 to 300 mg.

    Side effects:
    drowsiness, tachycardia, dry mouth, increased sweating or difficulty of accommodation. These side effects usually occur at the beginning of therapy, often disappear as its continuation. Orthostatic hypotension can occur, especially when applied in high  Dizziness, dysmenorrhea, skin rashes, constipation is rare. Extrapyramidal symptoms are especially rare. Described isolated cases decrease seizure threshold, occurrence of benign transient leukopenia and hemolytic anemia. With prolonged use, especially in high doses, can be observed: cholestatic jaundice, galactorrhea, gynecomastia, weakening of potency and libido, increased appetite, weight gain.

    Overdose symptoms. Sleepiness, hypo or hyperthermia, extrapyramidal symptoms, convulsions, shock, coma. Treatment. Symptomatic and supportive. As soon as possible should be made a gastric lavage, we recommend the use of the sorbent. Measures should be taken, aimed at maintaining the activity of the respiratory and cardiovascular systems. Do not use epinephrine, because this can lead to a subsequent decrease in blood pressure. Seizures can be cut short with diazepam and extrapyramidal symptoms biperidenom.

    Interaction with other drugs
    depressing effect chlorprothixene the central nervous system may be enhanced when taken with ethanol and ethanol-containing drugs, anesthetics, opioids, sedatives, hypnotics, neuroleptics.
    Anticholinergic action chlorprothixene enhanced by concomitant use of anticholinergics, antihistamines and antiparkinsonian agents.
    The drug enhances the action antihypertensive drugs.
    The simultaneous use of chlorprothixene and epinephrine may lead to hypotension and tachycardia.
    application chlorprothixene leads to a decrease in seizure activity threshold that requires an additional dose adjustment of antiepileptic drugs in patients with epilepsy.
    The ability chlorprothixene block dopamine receptors reduces the effectiveness of levodopa action.
    Perhaps the emergence of extrapyramidal disorders while the use of phenothiazines, metoclopramide, haloperidol, reserpine.

    Cautions
    Truksal should be prescribed with care in patients with epilepsy,  in severe cerebral arteriosclerosis, the tendency to collapse, with severe cardiovascular and respiratory failure, when expressed violations of liver and kidney function, diabetes, prostatic hypertrophy.
    Application Truksala can lead to false positive results during immunobiological urine pregnancy test falsely elevated levels of bilirubin in the blood, changes in the anadrol 50 dosage interval on the electrocardiogram.
    during treatment Truksalom to refrain from drinking alcohol, avoid high insolation.
    Reception Truksala has a negative impact on activities requiring a high rate of mental and physical reactions (eg, management of vehicles, machinery maintenance, work at height, etc.).